Digital Evidence Base

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Supra-annular sizing of transcatheter aortic valve prostheses in raphe-type bicuspid aortic valve disease: the LIRA method
Iannopollo G, Romano V, Buzzatti N, Ancona M, Ferri L, Russo F, Bellini B, Granada JF, Chieffo A, Montorfano M
2020
DOI: 10.1016/j.ijcard.2020.05.076

Background: Recent evidence shows that THV prostheses anchoring occurs at the raphe-level, known as LIRA plane, in raphe-type bicuspid aortic valve (BAV) disease. The purpose of this study was to …

Abstract
Genetic Cluster Analysis for HIV Prevention
Grabowski Mary Kate, Herbeck Joshua T., Poon Art F. Y.
2018

MEDLINE Abstract: PURPOSE OF REVIEW:<BR>This review summarizes the use of genetic similarity clusters to understand HIV transmission and inform prevention efforts.<BR>RECENT FINDINGS:<BR>Recent emphases include the development of real-time cluster identification …

Abstract
The Effect of Motivational Interviewing-Based Counseling During Outpatient Provider Initiated HIV Testing on High-Risk Sexual Behavior in Rural Uganda
Wanyenze RK, Bateganya MH, Lule H, Kiene SM
2016
DOI: 10.1007/s10461-016-1377-y

Provider-initiated HIV testing and counseling (PITC) has rapidly expanded in many countries including Uganda. However, because it provides HIV prevention information without individualized risk assessment and risk reduction counseling it …

Abstract
Efficacy and Safety of Switching to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide (E/C/F/TAF) in Virologically Suppressed Women
Kityo Cissy, Hodder Sally, Squires Kathleen, Hagins Debbie, Avihingsanon Anchalee, Kido Anna, Kulkarni Rima, Cheng Andrew, Shuping Jiang, Huyen Cao
2018
DOI: 10.1097/QAI.0000000000001663

Background: The integrase inhibitor regimen [elvitegravir/cobicistat/ emtricitabine/tenofovir disoproxil fumarate (TDF)] demonstrated superior efficacy when compared with a protease inhibitor regimen [ritonavir-boosted atazanavir (ATV + RTV) and FTC/TDF] in 575 treatment-naive …

Abstract
Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis
Giugliano Robert P., Pedersen Terje R., Saver Jeffrey L., Sever Peter S., Keech Anthony C., Bohula Erin A., Murphy Sabina A., Wasserman Scott M., Honarpour Narimon, Wang Huei, Lira Pineda Armando, Sabatine Marc S.
2020
DOI: 10.1161/STROKEAHA.119.027759

Background and Purpose- The PCSK9 (proprotein convertase subtilisin-kexin type 9) monoclonal antibody evolocumab lowered LDL (low-density lipoprotein) cholesterol by 59% to 0.8 (0.5-1.2) mmol/L and significantly reduced major vascular events …

Abstract
Realtime adherence monitoring of antiretroviral therapy among HIV-infected adults and children in rural Uganda
Haberer JE, Muzoora C, Bangsberg DR, Kiwanuka J, Nansera D, Hunt PW, So J, O'Donnell M, Siedner M, Martin JN
2013
DOI: 10.1097/QAD.0b013e328363b53f

A real-time wireless electronic adherence monitor (EAM) and weekly self-report of missed doses via interactive voice response (IVR) and short message service (SMS) queries were used to measure anti-retroviral therapy …

Abstract
The Effects of Maternal Diet and Breastfeeding on Children with Asthma and Allergy
Revelas Angela, Katasos Theodoros
2012

The increase in the prevalence of asthma and allergic diseases highlights the need for devising effective prevention strategies. Several studies have investigated the preventive effect of maternal avoidance of highly …

Abstract
Factors associated with uptake of community client-led ART delivery model at Mulago adult HIV clinic _ Mulago National Referral Hospital
Kizito O., Sabiti L.
2021
DOI: 10.1080/2331205X.2021.1896427

Community Client Led ART Delivery (CCLAD) model in Uganda refers to self-formed groups of six to eight stable Anti Retro viral Therapy (ART) patients from the same community or area. …

Abstract
Tools for Supporting the MCH Workforce in Addressing Complex Challenges: A Scoping Review of System Dynamics Modeling in Maternal and Child Health
Guynn Isabella, Simon Jessica, Anderson Seri, Klaman Stacey L., Mullenix Amy, Cilenti Dorothy, Hassmiller Lich Kristen
2022
DOI: 10.1007/s10995-022-03376-8

ObjectivesSystem Dynamics (SD) is a promising decision support modeling approach for growing shared understanding of complex maternal and child health (MCH) trends. We sought to inventory published applications of SD …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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