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Virological failure on first-line antiretroviral therapy; associated factors and a pragmatic approach for switching to second line therapyâEvidence from a prospective cohort study in rural south-western Uganda, 2004-2011
Levin J, Kaleebu P, Kazooba P, Masiira B, Mayanja B N
2018
DOI: 10.11604/pamj.2018.29.191.11940

Introduction: We investigated factors affecting Virological failure (VF) on first line Antiretroviral Therapy (ART) and evaluated a pragmaticapproach to switching to second line ART. Methods: Between 2004 and 2011, we …

Abstract
A Phase 1/2 Study of a Multiclade HIV-1 DNA Plasmid Prime and Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV-Uninfected East Africans (RV 172)
Kibuuka Hannah, Kimutai Robert, Maboko Leonard, Sawe Fred, Schunk Mirjam S., Arne Kroidl, Shaffer Douglas, Eller Leigh Anne, Kibaya Rukia, Eller Michael A., Schindler Karin B., Schuetz Alexandra, Millard Monica, Kroll Jason, Dally Len, Hoelscher Michael, Bailer Robert, Cox Josephine H., Marovich Mary, Birx Deborah L.
2010
DOI: 10.1086/650299

Background. Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multiclade DNA vaccine prime with a replication-defective recombinant adenovirus serotype 5 …

Abstract
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes NCT02163447 NCT
Kakuru A, Natureeba P, Dorsey G, Olwoch P, Kamya M R, Ategeka J, Jagannathan P, Clark T D, Nakalembe M, Muhindo M K, Kapisi J, Havlir D V, Nayebare P, Awori P, Rizzuto G, Muehlenbachs A, Ssekitoleko R, Gaw S L
2017
DOI: 10.1186/s12936-017-2040-4

BackgroundMalaria in pregnancy has been associated with maternal morbidity, placental malaria, and adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of malaria during pregnancy, measures …

Abstract
Oxidative stress in anterior segment of acute primary angle-closure eyes and its correlation with senescence-associated secretory phenotype
Huang J., Ye D., Xu Y.
2021

Purpose : Sudden and dramatic elevation of intraocular pressure (IOP) in acute primary angle closure (APAC) can lead to pathological changes of anterior segment. So far, the mechanisms that connect …

Abstract
Prevalence and correlates of abdominal obesity among adults in Uganda: Findings from a national cross-sectional, population based survey 2014 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sciences 1103 Clinica
Guwatudde D, Mutungi G, Wesonga R, Kabwama S N, Kirunda B, Bahendeka S K
2018
DOI: 10.1186/s40608-018-0217-1

BackgroundOverweight and obesity are associated with health complications the gravity of which, vary with the regional deposition of the excess fat. The Body Mass Index (BMI) is often used to …

Abstract
Role of the CD4 count in HIV management
Colebunders Robert, Hoffman Jennifer, Van Griensven Johan
2010
DOI: 10.2217/hiv.09.58

As a result of successful antiretroviral treatment over the last 20 years, HIV has become more of a chronic disease for practitioners to manage, requiring careful, but routine, clinical monitoring. …

Abstract
Comparison of Lowenstein-Jensen and BACTEC MGIT 960 culture for Mycobacterium tuberculosis in people living with HIV
Musaazi J, Eberhard N, Hongler J, Castelnuovo B, Fehr J, Sekaggya-Wiltshire C, Ledergerber B, Keller PM
2018
DOI: 10.1111/hiv.12635

ObjectivesThe aim of the study was to clarify how HIV infection affects tuberculosis liquid and solid culture results in a resource-limited setting.MethodsWe used baseline data from the Study on Outcomes …

Abstract
Prevalence and risk factors for neural axis anomalies in idiopathic scoliosis: a systematic review
Heemskerk Johan L., Kruyt Moyo C., Colo Dino, Castelein René M., Kempen Diederik H. R.
2018
DOI: 10.1016/j.spinee.2018.02.013

Background: There is ongoing controversy about the routine use of magnetic resonance imaging (MRI) preoperatively in patients with presumed idiopathic scoliosis (IS). Routine MRI can help identify possible causes for …

Abstract
Prevalence of Gastrointestinal Pathogens in Sub-Saharan Africa: Systematic Review and Meta-Analysis
Ellis J, Fletcher S. M, Stark D
2011

A significant proportion of vulnerable people in sub-Saharan Africa (SSA) remain at risk for contracting diarrhoeal diseases due to the presence of many risk factors facilitating their transmission. A systematic …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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