Digital Evidence Base

Trusted Knowledge for Informed Decisions

Publish Evidence AI Chat Login
Filters
SDGs
Priority Areas
Research Outcomes
Document Type
Year
4019 results found
Show:
The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young Ugandan Children
Kakuru A, Wanzira H, Kamya MR, Tappero JW, Arinaitwe E, Dorsey G, Homsy J, Bigira V, Muhindo M, Jagannathan P, Osilo E
2013
DOI: 10.4269/ajtmh.12-0654

Artemisinin-based combination therapies (ACTs) and trimethoprim-sulfamethoxazole (TS) prophylaxis are important tools for malaria control, but there are concerns about their effect on gametocytes, the stage of the parasite responsible for …

Abstract
Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected ugandan children
Achan J, Kakuru A, Ikilezi G, Mwangwa F, Charlebois E, Havlir D, Ruel T, Arinaitwe E, Dorsey G, Kamya M R, Rosenthal P J, Clark T D, Muhindo M K, Tappero J W
2014
DOI: 10.1093/cid/ciu286

Background.âArtemisinin-based combination therapies (ACTs) are highly efficacious and safe, but data from human immunodeficiency virus (HIV)âinfected children concurrently receiving antiretroviral therapy (ART) and ACTs are limited.Methods.âWe evaluated 28-day outcomes following …

Abstract
Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy
Kakuru A, Natureeba P, Clark TD, Kamya MR, Havlir DV, Dorsey G, Olwoch P, Charlebois ED, Ategeka J, Jagannathan P, Opira B, Nakalembe M, Muhindo MK, Feeney ME, Nayebare P, Awori P, Rizzuto G, Muehlenbachs A
2016
DOI: 10.1056/NEJMoa1509150

BACKGROUNDIntermittent treatment with sulfadoxine-pyrimethamine is widely recommended for the prevention of malaria in pregnant women in Africa. However, with the spread of resistance to sulfadoxine-pyrimethamine, new interventions are needed.METHODSWe conducted …

Abstract
Malaria burden in a birth cohort of HIV-exposed uninfected Ugandan infants living in a high malaria transmission setting
Kakuru A, Ruel T, Natureeba P, Cohan D, Dorsey G, Kamya M R, Clark T D, Muhindo M K, Havlir D V
2016
DOI: 10.1186/s12936-016-1568-z

AbstractBackground: HIV-exposed, uninfected (HEU) infants suffer high morbidity and mortality in the first year of life compared to HIV-unexposed, uninfected (HUU) infants, but accurate data on the contribution of malaria …

Abstract
ASSOCIATION BETWEEN INDOOR RESIDUAL SPRAYING OF INSECTICIDE AND IMPROVED BIRTH OUTCOMES AMONG HIV-INFECTED PREGNANT WOMEN IN UGANDA
et al, Kakuru A., Koss C., Natureeba P., Roh M., Shiboski S., Global Health Group Malaria Elimination Initiative U. S. A.
2017

WATERLIT Abstract: Despite effective interventions to prevent malaria during pregnancy, the risk of adverse birth outcomes among HIV-infected pregnant women living in sub-Saharan Africa remains high. A recent study demonstrated …

Abstract
Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review
Dorsey G., Kakuru A., Staedke S. G., Rogerson S., Chandramohan D.
2019
DOI: 10.1186/s12936-019-2943-3

BACKGROUND: Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact …

Abstract
Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: A randomized controlled trial
Dorsey G., Kajubi R., Jagannathan P., Ochieng T., Kakuru A., Kamya M.R., Clark T.D., Havlir D.V., Chandramohan D., Ochokoru H., Nakalembe M., Ruel T., Staedke S.G.
2020
DOI: 10.1186/s12916-020-01675-x

Background: Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) significantly reduces the burden of malaria during pregnancy compared to sulfadoxine-pyrimethamine (SP), the current standard of care, but …

Abstract
Infant sex modifies associations between placental malaria and risk of malaria in infancy
Dorsey G., Kajubi R., Jagannathan P., Ochieng T., Kakuru A., Kamya M.R., Clark T.D., Havlir D.V., Chandramohan D., Ochokoru H., Nakalembe M., Ruel T., Staedke S.G., Roh M.E., Ategeka J.
2020
DOI: 10.1186/s12936-020-03522-z

Background: Placental malaria (PM) has been associated with a higher risk of malaria during infancy. However, it is unclear whether this association is causal, and is modified by infant sex, …

Abstract
Central Nervous System Tumors in Uganda: Outcomes of Surgical Treatment and Complications Assessed Through Telephone Survey
Haglund MM, Kiryabwire J, Muhumuza M, Ssenyonjo H, Mukasa J, Vaca SD, Nalwanga J, Grant GA, Kakusa BW, Xu LW
2019
DOI: 10.1016/j.wneu.2019.06.060

BACKGROUND: Uganda has one of the largest unmet neurosurgical needs in the world, but has seen major improvements in neurosurgery-largely centered at Mulago National Referral Hospital (MNRH). This study implements …

Abstract
The association between dietary diversity and development among children under 24 months in rural Uganda: analysis of a cluster-randomised maternal education trial
Kakwangire P, Iversen PO, Westerberg AC, Muhoozi G, Atukunda P, Moss C, Matovu N
2021
DOI: 10.1017/S136898002100077X

Objective: To assess the association between dietary diversity and development among children under 24 months in rural Uganda and to establish other factors that could be associated with development among …

Abstract
AI Research Assistant
AI-powered research assistance. Uses the Digital Evidence Base as the Knowledge source.