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Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria
Kain K.C., Kim H., Dhabangi A., Musoke C., Erdman L.K., Lu Z., Serghides L., Zhong K., Gerard C., Cserti-Gazdewich C., Conrad Liles W.
2014
DOI: 10.1128/IAI.01246-13
Abstract
Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria
Opoka RO, Bangirana P, John CC, Idro R, Holmberg D, Franzen-Rohl E, Sellgren CM, Wickstrom R, Farnert A, Schwieler L, Engberg G
2017
DOI: 10.1186/s12936-017-1954-1

Background: One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor …

Abstract
Antenatal care and uptake of HIV testing among pregnant women in sub-Saharan Africa: a cross-sectional study
Gunn JKL, Asaolu IO, Center KE, Gibson SJ, Wightman P, Ezeanolue EE, Ehiri JE
2016
DOI: 10.7448/IAS.19.1.20605

Introduction: Current guidelines recommend inclusion of HIV testing in routine screening tests for all pregnant women. For this reason, antenatal care (ANC) represents a vital component of efforts to prevent …

Abstract
IBreath: An education intervention to improve lung health in Uganda
Kayingo G.
2019
DOI: 10.1097/01.JAA.0000603048.44891.02
Abstract
Deep gene sequence cluster analyses of multi-virus-infected mucosal tissue reveal enhanced transmission of acute HIV-1
Klein K., Nankya I., Nickel G., Ratcliff A.N., Meadows A.A.J., Hathaway N., Bailey J.A., Stieh D.J., Cheeseman H.M., Carias A.M., Lobritz M.A., Mann J.F.S., Gao Y., Hope T.J., Shattock R.J., Arts E.J.
2021
DOI: 10.1128/JVI.01737-20

Exposure of the genital mucosa to a genetically diverse viral swarm from the donor HIV-1 can result in breakthrough and systemic infection by a single transmitted/founder (TF) virus in the …

Abstract
Efavirenz-Based Antiretroviral Therapy Reduces Artemether-Lumefantrine Exposure for Malaria Treatment in HIV-Infected Pregnant Women
Hughes E, Mwebaza N, Huang LS, Kajubi R, Nguyen V, Nyunt MM, Orukan F, Mwima MW, Parikh S, Aweeka F
2020
DOI: 10.1097/QAI.0000000000002237

Background: The choice of malaria treatment for HIV-infected pregnant women receiving efavirenz-based antiretroviral therapy must consider the potential impact of drug interactions on antimalarial exposure and clinical response. The aim …

Abstract
Prognostic accuracy of antenatal Doppler ultrasound for adverse perinatal outcomes in low-income and middle-income countries: A systematic review
Ali S., Klipstein-Grobusch K., Heuving S., Kawooya M.G., Byamugisha J., Grobbee D.E., Papageorghiou A.T., Rijken M.J.
2021
DOI: 10.1136/bmjopen-2021-049799

Objectives This systematic review examined available literature on the prognostic accuracy of Doppler ultrasound for adverse perinatal outcomes in low/middle-income countries (LMIC). Design We searched PubMed, Embase, Cochrane Library and …

Abstract
High Mortality Associated with Retreatment of Tuberculosis in a Clinic in Kampala, Uganda: A Retrospective Study
Worodria W, Acuna-Villaorduna C, Ayakaka I, Dryden-Peterson S, Nakubulwa S, Reilly N, Hosford J, Fennelly KP, Okwera A, Jones-Lopez EC
2015
DOI: 10.4269/ajtmh.14-0810

The World Health Organization recommends for tuberculosis retreatment a regimen of isoniazid (H), rifampicin (R), ethambutol (E), pyrazinamide (Z), and streptomycin (S) for 2 months, followed by H, R, E, …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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