Digital Evidence Base

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Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T-b. rhodesiense in Uganda
Bardosh KL, Picozzi K, Waiswa C, Welburn SC, Hamill L, Fyfe J, von Wissmann B, Wastling S, Wardrop N, Selby R, Acup CA, Muhanguzi D, Kabasa JD
2017
DOI: 10.1186/s40249-016-0224-8

Background: Uganda has suffered from a series of epidemics of Human African Trypanosomiasis (HAT), a tsetse transmitted disease, also known as sleeping sickness. The area affected by acute Trypanosoma brucei …

Abstract
The Road Traffic Injuries Research Network: a decade of research capacity strengthening in low- and middle-income countries
HyderAdnan A., Norton Robyn, Pérez-Núñez Ricardo, Mojarro-Iñiguez Francisco R., Peden Margie, Kobusingye Olive
2016

MEDLINE Abstract: Road traffic crashes have been an increasing threat to the wellbeing of road users worldwide; an unacceptably high number of people die or become disabled from them. While …

Abstract
Community engagement for COVID-19 prevention and control: a rapid evidence synthesis
GilmoreBrynne, Ndejjo Rawlance, Tchetchia Adalbert, de Claro Vergil, Mago Elizabeth, Diallo Alpha A., Lopes Claudia, Bhattacharyya Sanghita
2020

MEDLINE Abstract: INTRODUCTION:<BR>Community engagement has been considered a fundamental component of past outbreaks, such as Ebola. However, there is concern over the lack of involvement of communities and 'bottom-up' approaches …

Abstract
Bronchial sleeve resection for early-stage squamous cell carcinoma
Goto Taichiro, Maeshima Arafumi, Akanabe Kumi, Kato Ryoichi
2012
DOI: 10.1186/1749-8090-7-33

A 75-year-old man complained of sputum and was referred to our department. His sputum cytology was class III. Chest X-ray and computed tomography showed no abnormalities, but bronchoscopy revealed an …

Abstract
Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: Implications for efavirenz dosing in HIV infection
Jamshidi Y, Moreton M, McKeown D A, Andrews S, Nithiyananthan T, Tinworth L, Holt D W, Sadiq S T
2010
DOI: 10.1093/jac/dkq369

Objectives: To determine differences in CYP2B6 loss of function (LoF) single nucleotide polymorphisms (SNPs)and haplotypes between Zimbabweans and Ugandans, and within Ugandan populations (Bantu and Nilotic).Methods: Genetic epidemiological study enrolling …

Abstract
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
Jaffar S., Muzoora C., Kanyama C., Jarvis J.N., Lawrence D.S., Meya D.B., Kagimu E., Kasibante J., Mpoza E., Rutakingirwa M.K., Ssebambulidde K., Tugume L., Rhein J., Boulware D.R., Mwandumba H.C., Moyo M., Singh A., Mzinganjira H., Hosseinipour M.C., Chawinga C., Meintjes G., Schutz C., Comins K., Jjunju S., Nuwagira E., Mosepele M., Leeme T., Siamisang K., Ndhlovu C.E., Hlupeni A., Mutata C., Van Widenfelt E., Chen T., Wang D., Hope W., Boyer-Chammard T., Loyse A., Molloy S.F., Youssouf N., Lortholary O., Lalloo D.G., Harrison T.S.
2022
DOI: 10.1056/NEJMoa2111904

Background: Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)- related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin …

Abstract
SAT-103 PREVALENCE AND PATTERN OF ECHOCARDIOGRAPHIC ABNORMALITIES AMONG PATIENTS ON HAEMODIALYSIS AT AN URBAN HOSPITAL IN UGANDA
Okello E., Ocama P., Kalyesubula R., Kansiime G.
2020
DOI: 10.1016/j.ekir.2020.02.111

Introduction: Cardiovascular disease is the most common cause of morbidity and premature mortality in patients on chronic haemodialysis. There is limited data on cardiac abnormalities among these patients in sub-Saharan …

Abstract
Bioinformatics mentorship in a resource limited setting
Joloba M., Jjingo D., Mboowa G., Sserwadda I., Kakaire R., Kiberu D., Amujal M., Galiwango R., Kateete D., Whalen C.C.
2022
DOI: 10.1093/bib/bbab399

BACKGROUND: The two recent simultaneous developments of high-throughput sequencing and increased computational power have brought bioinformatics to the forefront as an important tool for effective and efficient biomedical research. Consequently, …

Abstract
Highlights in this issue
Käll Anna, Lagercrantz Hugo
2015
DOI: 10.1111/apa.13246

An introduction is presented which discusses various topics within the issue including malnutrition in children with cerebral palsy in Uganda, hypoxic ischaemic encephalopathy (HIE) as a health problem worldwide and …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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