Digital Evidence Base

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Impact of large-scale health interventions on population health, economic functioning, and investments in human capital in Sub-Saharan Africa
Jakubowski Aleksandra
2018

Donations from the United States are a major source of global health funding. The United States invests a large portion of its global health aid portfolio in bilateral aid programs …

Abstract
Lymph node fibrosis: a structural barrier to unleashing effective vaccine immunity
Alter G, Julg B
2018
DOI: 10.1172/JCI121053

There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from …

Abstract
Utilizing a family-based economic strengthening intervention to improve mental health wellbeing among female adolescent orphans in Uganda
Ssewamala FM, Kivumbi A, Byansi W, Damulira C, Namatovu P, Proscovia N
2019
DOI: 10.1186/s13034-019-0273-4

BackgroundIt is estimated that almost 20% of the world's adolescents have experienced or are experiencing a mental health problem. Several factors have been associated with the onset of adolescent mental …

Abstract
Health services strengthening in Africa - research is a key component S. Jaffar et al
Corrah Tumani, Mboup Souleymane, Jaffar Shabbar, Lazarus Jeffrey V., Onyebujoh Philip, Chakaya Jeremiah, Garrib Anupam, Mwaba Peter, Bellis Kevin, Egwaga Saidi, Coutinho Alex
2010
DOI: 10.1111/j.1365-3156.2010.02626.x

The author reflects on the importance of strengthening the health services in Africa. He states that performing research is the most important part of the strengthening process. The major challenge …

Abstract
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study
Kamya MR, Rosenthal PJ, Bajunirwe F, Arinaitwe E, Drakeley C, Greenhouse B, Dorsey G, Rek J, Katureebe A, Kakande E, Nankabirwa JI, Walakira A, Nsobya SL, Rodriguez-Barraquer I
2020
DOI: 10.1186/s12936-020-3105-3

Background Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. …

Abstract
A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015
Hill VR, Kwesiga B, Bulage L, Zhu BP, Pande G, Nsubuga F, Oguttu DW, Masiira B, Okullo AE, Matovu J, Mafigiri R, Kihembo C, Kyazze S, Kabwama SN, Kajumbula H, Wetaka M, Sendagala JN, Musenero M, Nabukenya I, Mintz E, Kasozi S, Hughes P, Routh J, Gomez G, Dahlke M, Bicknese A, Makumbi I
2017
DOI: 10.1186/s12889-016-4002-0

Background: On 6 February 2015, Kampala city authorities alerted the Ugandan Ministry of Health of a "strange disease" that killed one person and sickened dozens. We conducted an epidemiologic investigation …

Abstract
Outcomes of pediatric second line antiretroviral therapy in low and middle income countries: A sytematic review
Kisitu Grace Paul
2014

Access to second line antiretroviral therapy (ART) for the treatment of HIV is on the rise and yet little is known about the effectiveness of second line ART in children …

Abstract
Dyspepsia Management in a Resource Poor Setting
Fadare J. O, Jemilohun A. C
2013

"Background: Dyspepsia has a significant impact on the quality of life of the sufferer; and results in enormous societal costs; either due to direct medical costs for physician visits; diagnostic …

Abstract
Invisible work: Child work in households with a person living with HIV/AIDS in Central Uganda
Abimanyi-Ochom J, Inder B, Hollingsworth B, Lorgelly P
2017
DOI: 10.1080/17290376.2017.1379429

Background: HIV/AIDS has led to increased mortality and morbidity, negatively impacting adult labour especially in HIV/ AIDS burdened Sub-Saharan Africa. There has been some exploration of the effects of HIV/AIDS …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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