The preponderance of global maternal and neonatal deaths occurs in low-resource countries. The risk factors that lead to these deaths are often detectable with ultrasound (US) and potentially preventable. We …
Objectives: To evaluate long-term virological failure (VF) and drug resistance among HIV-infected Ugandan chil-dren on first-line ART.Methods: In a multicentre prospective cohort study, viral load (VL) and drug resistance mutations …
Background: Clinical imaging guidelines (CIGs) have been demonstrated to reduce inappropriate diagnostic imaging. There is insufficient evidence for CIG effectiveness to reduce inappropriate imaging in Africa. We assessed the effectiveness …
Background: The inclusion of low and middle-income country (LMIC) hospitals in multicenter orthopaedic trials expands the pool of eligible patients and improves the external validity of the evidence. Furthermore, promoting …
Background: Surveillance forms the basis for response to disease outbreaks, including COVID-19. Herein, we identified the COVID-19 surveillance systems and the associated challenges in 13 African countries.Methods: We conducted a …
Purpose/Objective(s): Ampullary and Periampullary carcinomas (APAC) are uncommon gastrointestinal cancers that are often amenable to surgical resection. The benefit of postoperative adjuvant chemoradiotherapy (ACRT) in patients with completely resected localized …
Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository …
BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …