Digital Evidence Base

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Incidence of malaria by cotrimoxazole use in HIV-infected Ugandan adults on antiretroviral therapy: A randomised, placebo-controlled study
Levin J, Kamali A, Anywaine Z, Nunn A, Baisley K, Grosskurth H, Munderi P, Kasirye R P
2016
DOI: 10.1097/QAD.0000000000000956

Introduction: Previous unblinded trials have shown increased malaria amongHIV-infected adults on antiretroviral therapy (ART) who stop cotrimoxazole (CTX)prophylaxis. We investigated the effect of stopping CTX on malaria in HIV-infectedadults on …

Abstract
A framework to support the integration of priority setting in the preparedness, alert, control and evaluation stages of a disease pandemic
Bwire G., Kapiriri L., Essue B., Nouvet E., Kiwanuka S., Sengooba F., Reeleder D.
2022
DOI: 10.1080/17441692.2021.1931402

The COVID-19 pandemic, where the need-resource gap has necessitated decision makers in some contexts to ration access to life-saving interventions, has demonstrated the critical need for systematic and fair priority …

Abstract
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting
Serwanga A, Kiguba R, Ndagije HB, Nambasa V, Manirakiza L, Kirabira E, Olsson S, Speybroeck N, Mukonzo J
2020
DOI: 10.1186/s12936-020-03463-7

Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs. Yet, little has been done to promote the pharmacovigilance (PV) …

Abstract
Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirus
Rollin PE, Metcalfe MG, Gupta M, Goldsmith CS, Spipopoulou CF
2010
DOI: 10.1016/j.virol.2010.03.024

Bundibugyo ebolavirus is a newly identified Ebolavirus species. The virus was responsible for a recent hemorrhagic fever outbreak in Uganda with an approximate 30% case fatality rate. In this study, …

Abstract
Role of electroencephalogram in diagnosis of attention deficit hyper activity disorder
Ibrahim Alaa Zidan, Talat Mohammed Ahmed, Yossef Usama Mahmoud, Mohammed Amr Ibrahim
2019

Introduction: Attention deficit hyper activity disorder (ADHD), is the most prevalent neurodevelopmental disorder of childhood, which is characterized by the presence of inattention, hyperactivity, and/or impulsivity, EEG is the substrate …

Abstract
Phenotypic expression and prevalence of ESBL-producing Enterobacteriaceae in samples collected from patients in various wards of Mulago Hospital, Uganda
Kateregga JN, Kantume R, Atuhaire C, Lubowa MN, Ndukui JG
2015
DOI: 10.1186/s40360-015-0013-1

Background: Resistance to extended-spectrum cephalosporins among Enterobacteriaceae has been reported yet they serve as the last line treatment for severe infections in Uganda and other countries. This resistance often leads …

Abstract
The harms of internalized AIDS stigma: A comment on Tsai et al
Kalichman Seth C.
2013
DOI: 10.1007/s12160-013-9529-z

Comments on an article by Alexander C. Tsai et al. (see record [rid]2013-39537-007[/rid]). Alexander Tsai and colleagues reported that internalized stigma inhibits disclosure of HIV status among people living with …

Abstract
Power, policy and abortion care in Uganda
Kagaha A, Manderson L
2021
DOI: 10.1093/heapol/czaa136

Unsafe abortion practices remain the major contributor to maternal death in Uganda, impeding the achievement of universal health coverage and quality of maternal health care. Using an ethnographic design and …

Abstract
Capacity building for cancer prevention and early detection in the Ugandan primary healthcare facilities: Working toward reducing the unmet needs of cancer control services
Orem J, Jatho A, Mugisha NM, Kafeero J, Holoya G, Okuku F, Niyonzima N
2021
DOI: 10.1002/cam4.3659

Background In 2018, approximately 60,000 Ugandans were estimated to be suffering from cancer. It was also reported that only 5% of cancer patients access cancer care and 77% present with …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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