ACRES | Digital Evidence Base

4019 results found

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Integrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control

Mutungi G., Ssinabulya I., Neupane D., Schwartz J.I., Semitala F.C., Kimera I.D., Namugenyi C., Musimbaggo D.J., Ssenyonjo R., Atukunda P., Mugabe F., Ambangira F., Mbuliro M., Katwesigye R., Delles C., Muddu M.

2022

DOI: 10.1038/s41371-022-00655-3

Multi-month dispensing (MMD) is a patient-centered approach in which stable patients receive medicine refills of three months or more. In this pre-post longitudinal study, we determined hypertension and HIV treatment …

Abstract

Online interprofessional education for in-service health-care providers improved HIV performance indicators at health facilities in Uganda: a targeted training approach

Semitala F.C., Sewankambo N.K., Kimera I.D., Muddu M., Wanyina S., Bwayo D., Namusoke-Magongo E.

2022

DOI: 10.1016/S2214-109X(22)00153-X

Background: The Makerere University Education for Interprofessional HIV Service Delivery in Uganda capacity-building programme provides online, in-service interprofessional education to HIV health-care providers through a case-based approach. We used this …

Abstract

A food-based approach could improve dietary adequacy for 12â23-month-old Eastern Ugandan children

Kimere N C, Nambooze J, Lim H, Bulungu A L.S, Wellard K, Ferguson E L

2022

DOI: 10.1111/mcn.13311

Little is known about dietary adequacy, for young Ugandan children, or context-specific food choices to improve it. This study estimated the percentage of breastfed 12â23-month-old rural Eastern Ugandan children (nâ=â114) …

Abstract

Characterising antibody avidity in individuals of varied Mycobacterium tuberculosis infection status using surface plasmon resonance

Bagaya Bernard S., Kimuda Simon G., Biraro Irene Andia, Raynes John G., Cose Stephen

2018

MEDLINE Abstract: There is increasing evidence supporting a role for antibodies in protection against tuberculosis (TB), with functional antibodies being described in the latent state of TB infection. Antibody avidity …

Abstract

Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays

KimudaMagambo Phillip, Laming Dustin, Hoppe Heinrich C., Tastan Bishop Ãzlem

2019

MEDLINE Abstract: Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and …

Abstract

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection

Cose Stephen, KimudaSimon G., Nalwoga Angela, Levin Jonathan, Franken Kees L. M. C., Ottenhoff Tom H. M., Elliott Alison M., Andia-Biraro Irene

2017

MEDLINE Abstract: Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell …

Abstract

Protective effects of pioglitazone and/or liraglutide on pancreatic beta-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

Kimura T, Kaneto H, Shimoda M, Hirukawa H, Okauchi S, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto M, Kaku K

2015

DOI: 10.1016/j.mce.2014.11.018

The aim was to compare the protective effects of pioglitazone (PIO) and/or liraglutide (LIRA) on beta-cells with the progression of diabetes. Male db/db mice were treated with PIO and/or LIRA …

Abstract

Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme

Hailu A, Kimutai R, Musa AM, Njoroge S, Omollo R, Alves F, Khalil EAG, Diro E, Soipei P, Musa B, Salman K, Ritmeijer K, Chappuis F, Rashid J, Mohammed R, Jameneh A, Makonnen E, Olobo J, Okello L, Sagaki P, Strub N, Ellis S, Alvar J, Balasegaram M, Alirol E, Wasunna M

2017

DOI: 10.1007/s40261-016-0481-0

Introduction In 2010, WHO recommended a new first-line treatment for visceral leishmaniasis (VL) in Eastern Africa. The new treatment, a combination of intravenous (IV) or intramuscular (IM) sodium stibogluconate (SSG) …

Abstract

Incidence and risk predictors of acute kidney injury among HIV-positive patients presenting with sepsis in a low resource setting

Nuwagira E, Kimweri D, Muhindo R, Ategeka J, Muyindike W, Ceasor F

2021

DOI: 10.1186/s12882-021-02451-6

Background Acute kidney injury (AKI) is a frequently encountered clinical condition in critically ill patients and is associated with increased morbidity and mortality. In our resource-limited setting (RLS), the most …

Abstract

Burden, etiology and predictors of visual impairment among children attending Mulago National Referral Hospital eye clinic, Uganda

Kizito S, Kinengyere P, Kiggundu JB, Ampaire A, Wabulembo G

2017

DOI: 10.4314/ahs.v17i3.31

Background: Childhood visual impairment (CVI) has not been given due attention. Knowledge of CVI is important in planning preventive measures. The aim of this study was determine the prevalence, etiology …

Abstract

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