Digital Evidence Base

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HIGH PrEP UPTAKE and LOW HIV VIREMIA WHEN PrEP IS INTEGRATED into UGANDAN ART CLINICS
Mujugira A., Heffron R., Muwonge T., Thomas D., Nambi F., Nakabugo L., Kibuuka J., Feutz E.L., Meisner A.A., Thomas K.K., Ware N., Simoni J.A., Katz I.T., Kadama H.
2022

Background: Global scale-up of HIV (pre-exposure prophylaxis) PrEP includes targeting HIV-negative people in serodifferent partnerships with people living with HIV. There are few data to describe whether there is any …

Abstract
The effect of standard dose multivitamin supplementation on disease progression in HIV-infected adults initiating HAART: A randomized double blind placebo-controlled trial in Uganda
Manabe Y C, Guwatudde D, Bagenda D, Kyeyune R, Wamani H, Wang M, Ezeamama A E, Fawzi W W
2015
DOI: 10.1186/s12879-015-1082-x

AbstractBackground: Efficacy trials investigating the effect of multivitamin (MV) supplementations among patients onHighly Active Antiretroviral Therapy (HAART) have so far been inconclusive. We conducted a randomized, doubleblind, placebo controlled trial …

Abstract
Bacterial contamination of Ugandan paper currency notes possessed by food vendors around mulago hospital complex, Uganda
Allan M., Atuhaire C., Nathan M., Ejobi F., Cumber S.N.
2018
DOI: 10.11604/pamj.2018.31.143.16738
Abstract
A novel lung health programme addressing awareness and behaviour-change aiming to prevent chronic lung diseases in rural Uganda
Jones R, Kireng B, Buteme S, Williams S, van Gemertzs F
2019

Chronic lung disease is a huge, growing, but under-reported problem in Africa. Following a survey in rural Uganda, which found 16% of the adult population had COPD, we developed a …

Abstract
Patterns and treatment outcomes of anorectal malformations in Mbarara Regional Referral Hospital, Uganda
Kitya D, Situma M, Kayima P, Punchak M, Anderson GA
2019
DOI: 10.1016/j.jpedsurg.2018.07.019

Background/purpose: Anorectal malformation (ARM) is a common condition. Owing to scarcity of pediatric surgery services in Uganda, however, relatively little is known about this condition.Methods: This was a retrospective review …

Abstract
How do carers of disabled children cope? The ugandan perspective
Hartley S., Ojwang P., Baguwemu A., Ddamulira M., Chavuta A.
2017
Abstract
Lockdown measures in response to COVID-19 in nine sub-Saharan African countries
Zumla A, Musoke D, Ferrand RA, Haider N, Osman AY, Gadzekpo A, Akipede GO, Asogun D, Ansumana R, Lessells RJ, Khan P, Hamid MMA, Yeboah-Manu D, Mboera L, Shayo EH, Mmbaga BT, Urassa M, Kapata N, Kapata PC, Stigler F, Czypionka T, Kock R, McCoy D
2020
DOI: 10.1136/bmjgh-2020-003319

Lockdown measures have been introduced worldwide to contain the transmission of COVID-19. However, the term 'lockdown' is not well-defined. Indeed, WHO's reference to 'so-called lockdown measures' indicates the absence of …

Abstract
Performance of community health workers under integrated community case management of childhood illnesses in eastern Uganda
Karamagi C, Rutebemberwa E, Ssali S, Alfven T, Kalyango JN, Peterson S
2012
DOI: 10.1186/1475-2875-11-282

Background: Curative interventions delivered by community health workers (CHWs) were introduced to increase access to health services for children less than five years and have previously targeted single illnesses. However, …

Abstract
HIV-phyloTSI: Subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data
Abeler-Dörner L., Hall M., Wymant C., Bonsall D., Macintyre-Cockett G., Thomson L., Baeten J.M., Celum C.L., Galiwango R.M., Kosloff B., Limbada M., Mujugira A., Mugo N.R., Gall A., Blanquart F., Bakker M., Bezemer D., Ong S.H., Albert J., Bannert N., Fellay J., Gunsenheimer-Bartmeyer B., Günthard H.F., Kivelä P., Kouyos R.D., Meyer L., Porter K., van Sighem A., van der Valk M., Berkhout B., Kellam P., Cornelissen M., Reiss P., Ayles H., Burns D.N., Fidler S., Grabowski M.K., Herbeck J.T., Kagaayi J., Lingappa J.R., Ssemwanga D., Eshleman S.H., Cohen M.S., Ratmann O., Laeyendecker O., Fraser C., Hayes R., Kaleebu P., Golubchik T.
2022
DOI: 10.1101/2022.05.15.22275117

Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining duration of infection classify samples into …

Abstract
Apabetalone downregulates fibrotic, inflammatory and calcific processes in renal mesangial cells which may contribute to reduced cardiac events observed in ckd patients
Gilham D., Fu L., Rakai B., Wasiak S., Tsujikawa L., Halliday C., Sarsons C., Stotz S., Jahagirdar R., Johansson J., Sweeney M., Wong N., Kalantar-Zadeh K., Kulikowski E.
2021
DOI: 10.1093/ndt/gfab078.008

BACKGROUND AND AIMS: Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) …

Abstract
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