Simultaneous Quantification of Plasmodium Antigens and Host Factor C-Reactive Protein in Asymptomatic Individuals with Confirmed Malaria by Use of a Novel Multiplex Immunoassay

Malaria rapid diagnostic tests (RDTs) primarily detect Plasmodium falciparum antigen histidine-rich protein 2 (HRP2) and the malaria-conserved antigen lactate dehydrogenase (LDH) for P. vivax and other malaria species. The performance …

Multiplex human Malaria array: Quantifying antigens for malaria rapid diagnostics

Malaria antigen detection through rapid diagnostic tests (RDTs) is widely used to diagnose malaria and estimate prevalence. To support more sensitive next-generationRDTdevelopment and screen asymptomatic malaria,we developed and evaluated the …

Assessment of Plasmodium antigens and CRP in dried blood spots with multiplex malaria array

Dried blood spots (DBS) typically prepared on filter papers are an ideal sample type for malaria surveillance by offering easy and cost-effective methods in terms of sample collection, storage, and …

A PCR based HIV-1 test for point-of-care application

HIV-1 proviral DNA detection by PCR is the gold standard test for early diagnosis in infants. In resource limited settings, dried blood samples are transported from the point-of-care (POC) to …

Increased sensitivity of enterotoxigenic Escherichia coli detection in stool samples using oligonucleotide immobilized-magnetic nanoparticles

PCR detection of enterotoxigenic Escherichia-coli (ETEC) can be used directly on stool sample. However, it still has limitations due to presence of PCR inhibitors and interferences. This study, oligonucleotide primer …

Cost-effectiveness of rotavirus vaccination in children under five years of age in 195 countries: A meta-regression analysis

BackgroundRotavirus caused an estimated 151,714 deaths from diarrhea among children under 5 in 2019. To reduce mortality, countries are considering adding rotavirus vaccination to their routine immunization program. Cost-effectiveness analyses …

Civilâmilitary cooperation in the management of infectious disease outbreaks: a scoping review

IntroductionCivilâmilitary cooperation (CMC) in infectious disease outbreak responses has become more common, and has its own cooperation dynamics. These collaborations fit WHOâs call for multisectoral cooperation in managing health emergencies …

Priority setting: A method that incorporates a health equity lens and the social determinants of health

Research Question: This research adapted, tested, and evaluated a methodology to set priorities for systematic reviews topics within the Cochrane Collaboration that is sustainable and incorporates the social determinants of …

451: Progesterone, cervical cerclage and cervical pessary for primary prevention of preterm birth in high risk singleton pregnancies: a systematic review and network meta-analysis

Comparison of estimates of the nutrient density of the diet of women and children in Uganda by Household Consumption and Expenditures Surveys (HCES) and 24-hour recall

Background. Individual dietary intake data are important for informing national nutrition policy but are rarely available. National Household Consumption and Expenditures Surveys (HCES) may be an alternative method, but there …