A Stronger Innate Immune Response During Hyperacute Human Immunodeficiency Virus Type 1 (HIV-1) Infection Is Associated With Acute Retroviral Syndrome

Background: Acute retroviral syndrome (ARS) is associated with human immunodeficiency virus type 1 (HIV-1) subtype and disease progression, but the underlying immunopathological pathways are poorly understood. We aimed to elucidate …

Incidence and mortality of prostate cancer and their relationship with the Human Development Index worldwide

Background: The aim of this study was to evaluate the incidence and mortality of prostate cancer andtheir relationship with the Human Development Index (HDI) and its components in Asia in …

Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report

MEDLINE Abstract: A 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was …

Effectiveness of community-based cardiovascular disease prevention interventions to improve physical activity: A systematic review and meta-regression

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite preventive community-based interventions (CBIs) seem efficacious in reducing CVD risks, a comprehensive up-to-date synthesis on the effectiveness …

Considering the cultural context in psychopathology formulations

Background. Mental health research appears to be continually transforming. Recent literature reflects a greater appreciation for the ways in which pathoplastic features of culture modulate emotional regulation. This article introduces …

Central nervous system tumor distribution at a tertiary referral center in Uganda

Effects of scaling up various community-level interventions on child mortality in Burundi, Kenya, Rwanda, Uganda and Tanzania: a modeling study

BackgroundImproving child health remains one of the most significant health challenges in sub-Saharan Africa, a region that accounts for half of the global burden of under-five mortality despite having approximately …

Protocol for an interdisciplinary cross-sectional study investigating the social, biological and community-level drivers of antimicrobial resistance (AMR): Holistic Approach to Unravel Antibacterial Resistance in East Africa (HATUA)

IntroductionAntimicrobial resistance (AMR) is a global health threat that requires urgent research using a multidisciplinary approach. The biological drivers of AMR are well understood, but factors related to treatment seeking …

Laboratory investigations into the cause of multiple serious and fatal food poisoning incidents in Uganda during 2019

During 2019 a series of food poisoning events and deaths occurred in Uganda due to an unknown causative agent. In response the World Food Programme (WFP) initiated investigations into the …

Emergence and persistence of minor drug-resistant HIV-1 variants in Ugandan women after Nevirapine single-dose prophylaxis

Background: Nevirapine (NVP) single-dose is still a widely used antiretroviral prophylaxis for the prevention of verticalHIV-1 transmission in resource-limited settings. However, the main disadvantage of the Non-nucleoside ReverseTranscriptase Inhibitor (NNRTI) …