The impact of HIV and antiretroviral therapy on the cardiovascular system of HIV-infected children

Background Cardiovascular disease is increased in HIV-infected adults but the underlying aetiology is incompletely understood. Pre-clinical changes in cardiovascular structure and arterial stiffness in HIV-infected children are described in mainly …

Electrocardiographic Evidence of Cardiac Disease by Sex and HIV Serostatus in Mbarara, Uganda

Numerous studies in the United States and Europehave demonstrated an increased risk for cardiovasculardisease (CVD) among persons living with human immu-nodeficiency virus (PLWH) [1]. The relationship betweenhuman immunodeficiency virus (HIV) …

Sex-specific performance of the ASCVD pooled cohort equation risk calculator as a correlate of coronary artery calcium in Kampala, Uganda

Introduction: The prevalence of cardiovascular disease (CVD) is rising in Sub-Saharan Africa, but it is not known whether current risk assessment tools predict coronary atherosclerosis in the region. Furthermore, sex-specific …

Cost-effectiveness of rotavirus vaccination in Kenya and Uganda

IntroductionRotavirus vaccines have the potential to prevent a substantial amount of life-threatening gastroenteritis in young African children. This paper presents the results of prospective cost-effectiveness analyses for rotavirus vaccine introduction …

Should the threshold for a generalised HIV epidemic be 1% or 5%?

Who Knows Their Partner's HIV Status? Results From a Nationally Representative Survey in Uganda

Objective: We examine the extent to which Ugandans accurately know their HIV status and that of their partners.Methods: The 2011 Uganda AIDS Indicator Survey (UAIS) was a nationally representative study …

A population's higher-risk sexual behaviour is associated with its average sexual behaviour-An ecological analysis of subpopulations in Ethiopia, Kenya, South Africa, Uganda and the United States

Background: Given the large variation in the prevalence of sexually transmitted infections between populations it is important to characterize how sexual vary between populations. In this paper we assess how …

Antihypertensive Treatment in the Elderly

Hypertension is a major risk factor for cardiovascular disease; but it is also very prevalent in the community. These two factors combined prompted the World Health Organization (WHO) to report …

Management Issues in Hypertensive Diabetics

Diabetes mellitus and hypertension are common clinical conditions that often co-exist. This combination has been called the deadly duet to emphasise the increased cardiovascular risk when the two conditions co-exist. …

Angiotensin II Type 1 Receptor Antagonists and their Combinations in the Treatment of Hypertension

The pathophysiology of hypertension is not multifactorial in nature; and there is a complex interplay of mechanisms of control and counter-regulatory responses activated by drugs. The problem for clinicians is …