Cancer of the esophagus: histopathological sub-types in northern Uganda

Background: Esophageal cancer is the eighth most common cause of cancer death worldwide with squamous cell carcinoma and adenocarcinoma carcinoma as the main histopathological subtypes. Esophageal cancer is known for …

Magnitude of Cryptococcosis among HIV patients in sub-Saharan Africa countries: a systematic review and meta-analysis

Background: Cryptococcus is encapsulated opportunistic yeast that causes life threatening meningoencephalitis of patients with human immunodeficiency virus (HIV). The magnitude of Cryptococcosis among HIV patients varies from 1-10% in Western …

Coronary artery calcium, HIV and inflammation in Uganda compared with the USA

Objectives To compare the prevalence of detectable coronary artery calcium (CAC) among higher risk, older people living with HIV (PLWH) and uninfected persons in Uganda versus the USA, and second …

Strengthening capacity in hospitals to reduce perinatal morbidity and mortality through a codesigned intervention package: protocol for a realist evaluation as part of a stepped-wedge trial of the Action Leveraging Evidence to Reduce perinatal morTality a

Introduction Despite a strong evidence base for developing interventions to reduce child mortality and morbidity related to pregnancy and delivery, major knowledge-implementation gaps remain. The Action Leveraging Evidence to Reduce …

The impact of COVID-19 on Ugandan firms

The COVID-19 pandemic came at an enormous cost to both developed and developing countries, and Uganda is no exception to this. Though the country has so far been shielded from …

Trends in the Marginal Cost of Male Circumcision in Rural Rakai Uganda

Introduction: Male circumcision (MC) is an effective intervention to reduce HIV acquisition in men in Africa. We conducted a cost analysis using longitudinal data on expenditures on services and community …

Participants' experiences of engagement in community-centred mental health and psychosocial support programmes in conflict-affected communities within sub-Saharan Africa: a qualitative systematic review

Background Sub-Saharan Africa (SSA) experienced a burden of organised violence within 18 low-income and middle-income countries and hosted over 33 million displaced persons in 2019. Community-centred mental health and psychosocial …

Ambulatory Blood Pressure Profiles in a Subset of HIV-Positive Patients Pre and Post Antiretroviral Therapy : Cardiovascular Topic

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

The ASTRO-CM dose-finding pilot study investigated the role of adjunctive sertraline for thetreatment of HIV-associated cryptococcal meningitis in HIV-infected Ugandan patients. Thepresent study is a post-hoc pharmacokinetic-pharmacodynamic analysis of the …

Community acceptability of dolutegravir-based HIV treatment in women: a qualitative study in South Africa and Uganda

BackgroundDespite concerns about dolutegravir use in pregnancy, most low- and middle-income countries are accelerating the introduction of dolutegravir-based regimens into national antiretroviral treatment programmes. Questions remain about the acceptability of …