Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children

Nodding syndrome in Ugandan children-clinical features, brain imaging and complications: A case series

Objectives Nodding syndrome is a devastating neurological disorder of uncertain aetiology affecting children in Africa. There is no diagnostic test, and risk factors and symptoms that would allow early diagnosis …

Proposed guidelines for the management of nodding syndrome

Patients with nodding syndrome in Uganda improve with symptomatic treatment: A cross-sectional study

Objectives: Nodding syndrome (NS) is a poorlyunderstood neurological disorder affecting thousandsof children in Africa. In March 2012, we introduced atreatment intervention that aimed to providesymptomatic relief. This intervention included sodiumvalproate …

Cerebral malaria is associated with long-term mental health disorders: A cross sectional survey of a long-term cohort

Background: Cerebral malaria (CM) and severe malarial anaemia (SMA) are associated with neuroâdevelopmentalimpairment in African children, but longâterm mental health disorders in these children are not well defined.Methods: A cohort …

The natural history of nodding syndrome

MEDLINE Abstract: Nodding syndrome is a poorly understood acquired disorder affecting children in sub-Saharan Africa. The aetiology and pathogenesis are unknown, and no specific treatment is available. Affected children have …

Doxycycline for the treatment of nodding syndrome (DONS); the study protocol of a phase II randomised controlled trial

BackgroundNodding syndrome is a poorly understood neurological disorder of unknown aetiology, affecting several thousand children in Africa. There has been a consistent epidemiological association with infection by the filarial parasite, …

Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome

MEDLINE Abstract: Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have …

Trends in hepatitis B virus testing practices and management in HIV clinics across sub-Saharan Africa

Background: Approximately 8% of HIV-infected individuals are co-infected with hepatitis B virus (HBV) in sub-Saharan Africa (SSA). Knowledge of HBV status is important to guide optimal selection of antiretroviral therapy …

Impact of Universal Antiretroviral Treatment Eligibility on Rapid Treatment Initiation Among Young Adolescents with Human Immunodeficiency Virus in Sub-Saharan Africa

Background. Young adolescents with perinatally acquired human immunodeficiency virus (HIV) are at risk for poor care outcomes. We examined whether universal antiretroviral treatment (ART) eligibility policies (Treat All) improved rapid …